There is a toxin in bee venom that might be able to prevent the spread of ‘HIV, becoming the main molecule to develop a vaginal gel. Missing only one piece, once established that melittin, the name of the main component of the venom of these insects, is effective against the virus. The insert is a “container” that would allow the molecules to hit the virus, leaving healthy cells intact. Researchers at Washington University School of Medicine in St. Louis led by Joshua L. Hood have developed nanoparticles that may contain the toxin bringing it toward the target, the virus. The study was published in the journal Antiviral Therapy.
The toxin melittin is a very powerful can “pierce” the double membrane that protects the virus, HIV and more. However, in large quantities may also do serious damage to human cells. So Russell Hornsby, professor of biomedical sciences, and Samuel A. Wickline, are made in the laboratory of “bio-capsule” with bumpers that bounce on the cell surface and instead recognize and intercept the virus. The melittin shape of the hooks that attach the main part of the structure of HIV. An advantage over other therapies, the researchers said. While traditional medications block, in fact, the replication of the virus, but fail to stop the initial infection with the risk that HIV can circumvent their action, the toxin extracted from bee venom has proved effective against the virus itself .
“The base particle that we are using in these experiments was developed many years ago as a product of artificial blood,” says Hood. The researchers hope now to develop the carrier capable of carrying the “poison” in the blood without damaging the structure of the plasma cells and tissues. But they have no hope: the melittin could also be effective against hepatitis B and C.
Source (IlSole24Ore)
C’è una tossina nel veleno delle api che potrebbe essere in grado di impedire la diffusione dell’ Hiv, diventando la molecola principale per sviluppare un gel vaginale. Mancava solo un tassello, una volta appurato che la melittina, così si chiama il principale componente del veleno di questi insetti, è efficace contro il virus. Il tassello è un “contenitore” che permettesse alle molecole di colpire il virus, lasciando intatte le cellule sane. I ricercatori della Washington University School of Medicine di St. Louis guidati da Joshua L. Hood hanno messo a punto delle nanoparticelle che possono contenere la tossina portandola verso il bersaglio, il virus. Lo studio è stato pubblicato sulla rivista Antiviral Therapy.
La melittina è una tossina molto potente: riesce a “bucare” la doppia membrana che protegge i virus, Hiv ma non solo. Tuttavia, in grandi quantità rischia di fare seri danni anche per le cellule umane. Così Russell Hornsby, docente di Scienze biomedicali, e Samuel A. Wickline, hanno realizzato in laboratorio delle “bio-capsule” dotate di paraurti che rimbalzano sulla superficie delle cellule e invece riconoscono e intercettano il virus. La melittina forma degli uncini che attaccano la parte essenziale della struttura dell’Hiv. Un vantaggio rispetto alle altre terapie, spiegano i ricercatori. Mentre i farmaci tradizionali bloccano, infatti, la replicazione del virus, ma non riescono a fermare l’infezione iniziale con il rischio che l’Hiv può aggirare la loro azione, la tossina estratta dal veleno delle api si è dimostrata efficace contro il virus stesso.
“La particella di base che stiamo usando in questi esperimenti è stata sviluppata molti anni fa come prodotto di sangue artificiale,” spiega Hood. I ricercatori sperano adesso di mettere a punto il vettore in grado di trasportare il “veleno” nel sangue senza danneggiare la struttura delle cellule plasmatiche e dei tessuti. Ma nutrono più speranze: la melittina potrebbe essere efficace anche contro epatite B e C.
Fonte (ilsole24ore)
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