A drug used currently only for the treatment of anxiety and depression may soon be used to prevent heart problems. These are the results of a research conducted by the University of Michigan and published in the journal Chemical Biology.
According to the new study, a substance technically considered a selective inhibitor of serotonin (Ssri) works by blocking a receptor called kinase 2 (GRK2), a protein abundant in people who have a heart attack. Paroxetine has been on the market under the name Paxil.
Search through two thousand substances
This is the first study that shows a direct link between a specific Ssri and a protein linked to the contractility of the heart muscle, the myocardium.
The scientists studied more than two thousand substances that could block the protein GRK2 affecting the force of muscle contractions.
Paroxetine has been shown to improve the strength of the contractions of the heart in an animal model without interfering with the heartbeat.
Paxil is a drug duly approved by the Food and Drug Administration – the agency of the U.S. drug – and is used by about thirty years as an antidepressant.
Source (Tgcom)
Un medicinale impiegato attualmente solo per la cura di ansia e depressione potrebbe presto essere utilizzato per prevenire problemi cardiaci. Questi i risultati di una ricerca condotta dalla University of Michigan e pubblicata sulla rivista Chemical Biology.
Secondo il nuovo studio, una sostanza tecnicamente considerata un inibitore selettivo della serotonina (Ssri) agisce bloccando un recettore chiamato kinase 2 (Grk2), proteina abbondante nelle persone che hanno un attacco cardiaco. La paroxetina è presente sul mercato con il nome di Paxil.
Una ricerca tra duemila sostanze
Si tratta della prima ricerca che testimonia un legame diretto fra uno specifico Ssri e una proteina legata alla contrattilità del muscolo cardiaco, il miocardio.
Gli scienziati hanno esaminato oltre duemila sostanze che potessero bloccare la proteina Grk2 che incide sulla la forza delle contrazioni muscolari.
La paroxetina ha mostrato di migliorare la forza delle contrazioni del cuore in un modello animale senza interferire con il battito.
Il Paxil è un farmaco regolarmente approvato dalla Food and drug administration – l’agenzia del farmaco statunitense – e viene usato da circa trent’anni come antidepressivo.
Fonte (tgcom)
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