The development of regenerative therapies for cartilage lesions has been greatly helped by the recent progress in the field of stem cell biology. It was obtained the first tube cartilage in induced pluripotent stem (IPS), a rat. According to experts the technique could be used in the future to produce cartilage from human cells reprogrammed. The fabric may then be used to repair tissues and treat osteoarthritis, degenerative disease that affects the cartilage of the joints. “Research has shown – through experiments on lab rats – that you can create an unlimited amount of stem cells that can transform into any type of tissue,” said Farshid Guilak, professor of orthopedic surgery at Duke and lead author of the study. The experimentation examined the cartilage, connective tissue initially present in the embryo developing that, with the growth of the organism, is almost completely replaced by bone tissue. The remaining cartilage is a connective tissue in the joints of specialist support that allows you to move without pain. During the lifetime its durability and its functionality can be undermined by a number of factors (post-traumatic or degenerative) that expose the cartilage lesions more or less important and the onset of osteoarthritis. The articular cartilage, in fact, has a poor ability to repair. With this new discovery, we can then rebuild the damaged cartilage.
Lo sviluppo di terapie rigenerative per le lesioni della cartilagine è stato molto aiutato dai recenti progressi nel campo della biologia delle cellule staminali. È stata ottenuta la prima cartilagine in provetta da cellule staminali pluripotenti indotte (Ips), di topo. Secondo gli esperti la tecnica potrebbe essere usata in futuro per produrre cartilagine a partire da cellule umane riprogrammate. Il tessuto potrebbe quindi essere utilizzato per riparare i tessuti e curare la osteoartrite, malattia degenerativa che altera la cartilagine delle articolazioni. “La ricerca ha dimostrato – attraverso la sperimentazione su topi da laboratorio – che è possibile creare una quantità illimitata di cellule staminali capaci di trasformarsi in un qualsiasi tipo di tessuto”, ha detto Farshid Guilak, professore di Chirurgia ortopedica presso la Duke e primo autore dello studio. La sperimentazione ha preso in esame la cartilagine, un tessuto connettivo inizialmente presente nell’embrione in via di sviluppo che, con la crescita dell’organismo, viene quasi completamente sostituito dal tessuto osseo. Il tessuto cartilagineo rimanente è un tessuto connettivo di sostegno specializzato presente nelle articolazioni che permette di muoverci senza provare dolore. Durante l’arco della vita la sua resistenza e la sua funzionalità possono essere minate da una serie di fattori (post-traumatici o degenerativi) che espongono la cartilagine a lesioni più o meno importanti e alla comparsa dell’osteoartrite. La cartilagine articolare, infatti, ha una scarsa capacità di riparazione.
Grazie a questa nuova scoperta potremo quindi rigenerare la cartilagine lesionata.
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